Moclobemide (Systemic)
Brand Names : Manerix, RO 11–1163.
Before Using This MedicineIn deciding
to use a medicine, the risks of taking the medicine must be weighed against
the good it will do. This is a decision you and your doctor will make. For
moclobemide, the following should be considered:
Allergies - Tell your doctor if you have ever had any unusual
or allergic reaction to moclobemide or monoamine oxidase inhibitors. Also
tell your doctor and pharmacist if you are allergic to any other substances,
such as foods, preservatives, or dyes.
Diet -
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Ask your doctor about any changes you should make to your diet.
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Do not drink excessive amounts of alcohol while you are taking this
medicine.
Pregnancy - Studies of moclobemide use in pregnant women have
not been done. In some animal studies, weight gain was decreased in pregnant
females or their offspring after high doses of moclobemide. Before taking
this medicine, make sure your doctor knows if you are pregnant or if you may
become pregnant.
Breast-feeding - Small quantities of moclobemide pass into the
breast milk. Moclobemide is not recommended during breast-feeding, because
it may cause unwanted effects in nursing babies.
Children - Studies on moclobemide have been done only in adult
patients, and there is no specific information comparing use of moclobemide
in children with use in other age groups.
Older adults - Older adults are especially sensitive to the effects
of moclobemide. This may increase the chance of side effects during treatment.
Dizziness or lightheadedness may be especially likely to occur in elderly
patients, who are usually more sensitive than younger adults to these effects.
Other medicines - Although certain medicines should not be used
together at all, in other cases two different medicines may be used together
even if an interaction might occur. In these cases, your doctor may want to
change the dose, or other precautions may be necessary. When you are taking
moclobemide, it is especially important that your doctor and pharmacist know
if you are taking any of the following:
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Amphetamines or
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Appetite suppressants (diet pills) or
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Dextromethorphan or
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Medicine for asthma or other breathing problems
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Medicines for colds, sinus problems, or hay fever or other allergies
(including nose drops or sprays) or
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Meperidine (e.g., Demerol) or
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Selective serotonin reuptake inhibitor antidepressants (fluvoxamine
[e.g., Luvox], fluoxetine [e.g., Prozac], paroxetine [e.g., Paxil], sertraline
[e.g., Zoloft]) or
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Tricyclic antidepressants (amitriptyline [e.g., Elavil], amoxapine
[e.g., Asendin], clomipramine [e.g., Anafranil], desipramine [e.g., Norpramin],
doxepin [e.g., Sinequan], imipramine [e.g., Tofranil], nortriptyline [e.g.,
Aventyl], protriptyline [e.g., Vivactil], trimipramine [e.g., Surmontil] - Using
these medicines together may increase the chance of serious side effects
-
Cimetidine (e.g., Tagamet) - May increase the effect of moclobemide;
moclobemide doses may need to be lowered by approximately 50% in patients
using cimetidine
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Monoamine oxidase (MAO) inhibitor activity (isocarboxazid
[e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane],
selegiline [e.g., Eldepryl], tranylcypromine [e.g., Parnate]) - Taking
moclobemide while you are taking or within 2 weeks of taking monoamine oxidase
(MAO) inhibitors may cause very serious side effects, such as sudden high
body temperature, extremely high blood pressure, and severe convulsions; at
least 14 days should be allowed between stopping treatment with one medicine
and starting treatment with the other
Other medical problems - The presence of other medical
problems may affect the use of moclobemide. Make sure you tell your doctor
if you have any other medical problems, especially:
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Hypertension - Moclobemide may make the problem worse
-
Liver disease - Effects of moclobemide may be increased because
of slower removal of the medicine from the body; your doctor may need to change
your dose
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