Piperazine (Systemic)
Brand Names : Entacyl
Before Using This MedicineIn deciding to use a medicine,
the risks of taking the medicine must be weighed against the good it will
do. This is a decision you and your doctor will make. For piperazine, the
following should be considered:
Allergies - Tell your doctor if you have ever had any unusual or
allergic reaction to piperazine or ethylenediamine. Also tell your health
care professional if you are allergic to any other substances, such as foods,
preservatives, or dyes.
Pregnancy - Piperazine has not been studied in pregnant women.
Piperazine has not been shown to cause birth defects or other problems in
animal studies. However, piperazine, taken by mouth, may be changed within
the body into a substance that may cause cancer. Before taking piperazine,
make sure your doctor knows if you are pregnant or if you may become pregnant.
Breast-feeding - It is not known whether piperazine passes into
breast milk. Although most medicines pass into breast milk in small amounts,
many of them may be used safely while breast-feeding. Mothers who are taking
this medicine and who wish to breast-feed should discuss this with their doctor.
Children - Children may be especially sensitive to the effects
of piperazine. This may increase the chance of side effects during treatment.
Older adults - Many medicines have not been studied specifically
in older people. Therefore, it may not be known whether they work exactly
the same way they do in younger adults or if they cause different side effects
or problems in older people. There is no specific information comparing use
of piperazine in the elderly with use in other age groups.
Other medicines - Although certain medicines should not be used
together at all, in other cases two different medicines may be used together
even if an interaction might occur. In these cases, your doctor may want to
change the dose, or other precautions may be necessary. When you are taking
piperazine, it is especially important that your health care professional
know if you are taking any of the following:
-
Phenothiazines (acetophenazine [e.g., Tindal], chlorpromazine [e.g.,
Thorazine], fluphenazine [e.g., Prolixin], mesoridazine [e.g., Serentil],
perphenazine[e.g., Trilafon], prochlorperazine [e.g., Compazine], promazine
[e.g., Sparine], promethazine [e.g., Phenergan], thioridazine [e.g., Mellaril],
trifluoperazine [e.g., Stelazine], triflupromazine [e.g., Vesprin], trimeprazine
[e.g., Temaril]) - Taking piperazine and a phenothiazine together may
increase the risk of convulsions (seizures)
-
Pyrantel (e.g., Antiminth) - Taking piperazine and pyrantel together
may decrease the effects of piperazine
Other medical problems - The presence of other medical
problems may affect the use of piperazine. Make sure you tell your doctor
if you have any other medical problems, especially:
-
Kidney disease or
-
Liver disease - Patients with kidney or liver disease may have
an increased chance of side effects
-
Seizure disorder, especially a history of epilepsy - Piperazine
may make the condition worse
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