Rifapentine (Systemic)
Brand Names : Priftin
Before Using This MedicineIn deciding to use a medicine,
the risks of taking the medicine must be weighed against the good it will
do. This is a decision you and your doctor will make. For rifapentine, the
following should be considered:
Allergies - Tell your doctor if you have ever had any unusual or
allergic reaction to rifabutin (e.g., Mycobutin), rifampin (e.g., Rifadin),
or rifapentine. Also tell your health care professional if you are allergic
to any other substances, such as foods, preservatives, or dyes.
Pregnancy - Use of rifapentine during the last few weeks of pregnancy
may rarely result in bleeding in the mother and newborn.
Breast-feeding - It is not known whether rifapentine passes into
the breast milk.
Children - Safety and efficacy have not been established in
infants and children younger than 12 years of age. For children 12 years of
age and older, rifapentine is not expected to cause different side effects
or problems than it does in adults.
Older adults - Rifapentine is not expected to cause different side
effects or problems in older people than it does in younger adults.
Other medicines - Although certain medicines should not be used
together at all, in other cases two different medicines may be used together
even if an interaction might occur. In these cases, your doctor may want to
change the dose, or other precautions may be necessary. When you are taking
rifapentine, it is especially important that your health care professional
know if you are taking any of the following:
-
Alcohol - Alcohol may increase the chance of liver damage if
taken with rifapentine
-
Antidiabetic agents, oral (diabetes medicine you take by mouth) or
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Chloramphenicol (e.g., Chloromycetin) or
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Ciprofloxacin (e.g., Cipro) or
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Clarithromycin (e.g., Biaxin) or
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Corticosteroids (cortisone-like medicine) or
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Delavirdine (e.g., Rescriptor) or
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Digitalis glycosides (heart medicine) or
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Diltiazem (e.g., Cardizem) or
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Disopyramide (e.g., Norpace) or
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Doxycycline (e.g., Vibramycin) or
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Estrogen-containing oral contraceptives (birth control pills) or
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Fluconazole (e.g., Diflucan) or
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Human immunodeficiency virus (HIV) protease inhibitors (medicines
for the treatment of HIV infection) or
-
Itraconazole (e.g., Sporanox) or
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Ketoconazole (e.g., Nizoral) or
-
Methadone (e.g., Dolophine) or
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Mexiletine (e.g., Mexitil) or
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Nifedipine (e.g., Procardia) or
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Phenytoin (e.g., Dilantin) or
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Quinidine (e.g., Quinidex) or
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Theophylline (e.g., Theo-dur) or
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Tocainide (e.g., Tonocard) or
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Verapamil (e.g., Calan) or
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Warfarin (e.g., Coumadin) or
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Zidovudine (e.g., AZT, Retrovir) - Rifapentine may decrease the
effects of these medicines. If you are taking oral contraceptives, this may
increase the chance of pregnancy.
Other medical problems - The presence of other medical
problems may affect the use of rifapentine. Make sure you tell your doctor
if you have any other medical problems, especially:
-
Alcohol abuse (or history of) or
-
Liver disease - There may be an increased chance of side effects
affecting the liver in patients with a history of alcohol abuse or liver disease
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