Ticlopidine (Systemic)
Brand Names : Ticlid
Before Using This MedicineIn deciding to use a medicine, the risks of taking the medicine must be
weighed against the good it will do. This is a decision you and your doctor
will make. For ticlopidine, the following should be considered:
Allergies - Tell your doctor if you have ever had any unusual or
allergic reaction to ticlopidine. Also tell your health care professional
if you are allergic to any other substances, such as foods, preservatives,
or dyes.
Pregnancy - Studies with ticlopidine have not been done in pregnant
women. This medicine did not cause birth defects in animal studies. However,
it caused other unwanted effects in animal studies when it was given in amounts
that were large enough to cause harmful effects in the mother.
Breast-feeding - It is not known whether ticlopidine passes into
the breast milk.
Children - There is no specific information comparing use of
ticlopidine in children with use in other age groups.
Older adults - This medicine has been tested and has not been shown
to cause different side effects or problems in older people than it does in
younger adults.
Other medicines - Although
certain medicines should not be used together at all, in other cases two different
medicines may be used together even if an interaction might occur. In these
cases, your doctor may want to change the dose, or other precautions may be
necessary. When you are taking ticlopidine, it is especially important that
your health care professional know if you are taking any of the following:
-
Anticoagulants (blood thinners) or
-
Aspirin or
-
Carbenicillin by injection (e.g., Geopen) or
-
Clopidogrel (e.g., Plavix) or
-
Dipyridamole (e.g., Persantine) or
-
Divalproex (e.g., Depakote) or
-
Heparin (e.g., Hepalean, Liquaemin) or
-
Inflammation or pain medicine, except narcotics or
-
Low molecular weight heparin (ardeparin [e.g., Normiflo], dalteparin
[e.g., Fragmin], enoxaparin [e.g., Lovenox], nadroparin [e.g., Fraxiparine])
or
-
Pentoxifylline (e.g., Trental) or
-
Plicamycin (e.g., Mithracin) or
-
Sulfinpyrazone (e.g., Anturane) or
-
Ticarcillin (e.g., Ticar) or
-
Valproic acid (e.g., Depakene) - The chance of serious bleeding
may be increased
-
Phenytoin (e.g., Dilantin) - Ticlopidine may increase the amount
of phenytoin in the blood and increase the chance of side effects from phenytoin
-
Xanthines such as theophylline (e.g. Theo-Dur) - Ticlopidine
may slow the elimination of theophylline and increase the chance of side effects
from theophylline
Other medical problems - The presence of other medical
problems may affect the use of ticlopidine. Make sure you tell your doctor
if you have any other medical problems, especially:
-
Blood clotting problems, such as hemophilia and von Willebrand's
disease, or
-
Liver disease (severe) or
-
Stomach ulcers - The chance of serious bleeding may be increased
-
Blood disease - The chance of serious side effects may be increased
-
Kidney disease (severe) - Ticlopidine is removed from the body
more slowly when the kidneys are not working properly. This may increase the
chance of side effects
Also, tell your doctor if you have ever had a problem called thrombotic
thrombocytopenic purpura (TTP). This problem could reoccur if you take ticlopidine.
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