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You are here : 3-RX.com > Drugs & Medications > Quick Drug Information (DrugNotes) > Cyproheptadine Hydrochloride (Oral)

Cyproheptadine Hydrochloride (By Mouth)

Cyproheptadine Hydrochloride (si proe-HEP-ta-deen hye-droe-KLOR-ide)

Treats hay fever, cold, and allergy symptoms such as runny nose, watery eyes, hives, and swelling. Belongs to a class of drugs called antihistamines.

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have ever had an allergic reaction to cyproheptadine or MAO inhibitors such as Marplan®, Nardil®, or Parnate®. Do not give this medicine to a newborn baby. You should not take cyproheptadine if you are breastfeeding, or have glaucoma, stomach ulcers, bladder or intestine problems, or an enlarged prostate.

How to Use This Medicine:

Tablet, Liquid

  • Your doctor will tell you how much medicine to take and how often.
  • You may take your medicine with food to avoid stomach upset.

If a dose is missed:

  • Take your medicine as soon as you remember that you have missed your dose.
  • If it is nearly time for your next dose, wait until then to take the medicine and skip the missed dose.
  • You should not use two doses at one time.
How to Store and Dispose of This Medicine:

  • Store at room temperature, away from moisture, heat, and light. Do not freeze.
  • Keep all medicine away from children.
Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Avoid drinking alcohol while taking cyproheptadine.
  • Avoid taking other medicines that may make you sleepy, such as other cold or allergy medicines, sleeping pills, sedatives, or tranquilizers.
  • Cyproheptadine should not be taken if you are also taking a monoamine oxidase (MAO) inhibitor such as Nardil®, Marplan®, or Parnate®.
Warnings While Using This Medicine:

  • If you are pregnant or breastfeeding, talk to your doctor before taking this medicine.
  • Let your doctor know if you have ever had asthma, heart disease, overactive thyroid, or high blood pressure.
  • Tell your doctor if you become pregnant while taking this medicine.
  • This medicine might make you drowsy. Be careful when driving or operating dangerous machinery.
Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Skin rash, hives, or itching
  • Irregular heartbeat
  • Hallucinations
  • Trouble breathing
  • Seizures (convulsions)

If you notice these less serious side effects, talk with your doctor:

  • Drowsiness
  • Dizziness
  • Restlessness
  • Trouble sleeping
  • Ringing or pressure inside ear
  • Dry mouth, nose, or throat
  • Stomach upset
  • Urinating more often
  • Headache
If you notice other side effects that you think are caused by this medicine, tell your doctor.


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