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You are here : 3-RX.com > Drugs & Medications > Quick Drug Information (DrugNotes) > Imiquimod (Topical)

Imiquimod (On The Skin)

Imiquimod (i-mi-KWI-mod)

Treats genital warts.

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to imiquimod.

How to Use This Medicine:


  • Your doctor will tell you how much medicine to use and how often. You may be told to use the cream 3 times each week (Monday-Wednesday- Friday OR Tuesday-Thursday-Saturday) right before you go to bed.
  • Keep using the cream until the warts are gone or up to 16 weeks. If you still have the warts after 16 weeks, talk with your doctor.
  • Use the cream only on your skin. Do not get the medicine in your eyes. You should not use the medicine inside your vagina or anus.
  • Wash your hands with soap and water before and after you use this medicine.
  • Put a thin layer of cream over the warts and gently rub the cream into your skin.
  • Do not bandage or tightly wrap the area so that air cannot get to it. You may use gauze over the area, or wear cotton underwear.
  • Leave the cream on for 6 to 10 hours. Then wash the cream off using a mild soap and water.

If a dose is missed:

  • Use the medicine as soon as possible, unless it is almost time for your next dose.
  • Skip the missed dose if it is almost time for your next regular dose.
  • Do not put on two doses at the same time.
How to Store and Dispose of This Medicine:

  • Store the cream at room temperature away from heat and moisture. Do not freeze.
  • Keep all medicine out of the reach of children.
Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

  • If you are pregnant or breastfeeding, talk to your doctor before using this medicine.
  • Do not have sex while being treated for warts, even if you or your partner are using a condom. The cream can weaken condoms and diaphragms, so you and your partner may be unprotected during sex.
  • Imiquimod is not a cure for genital or anal warts, so you may develop new warts while using the cream.
Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Severe skin burning, pain, or peeling
  • Open sores where you use the medicine

If you notice these less serious side effects, talk with your doctor:

  • Mild skin redness, swelling, flaking, or dryness
  • Itching
  • Headache, muscle pain, or feeling like you have the flu
If you notice other side effects that you think are caused by this medicine, tell your doctor.

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