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You are here : 3-RX.com > Drugs & Medications > Quick Drug Information (DrugNotes) > Trazodone (Oral)

Trazodone (By Mouth)

Trazodone (TRAZ-oh-done)

Treats depression and depression with anxiety.

Brand Name(s):

Desyrel, Desyrel Dividose
There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to trazodone.

How to Use This Medicine:


  • Your doctor will tell you how much to take and how often.
  • Take your medicine with food or shortly after eating.

If a dose is missed:

  • Take the missed dose as soon as possible.
  • If it is almost time for your next regular dose, wait until then to take your medicine and skip the missed dose.
  • You should not use two doses at the same time.
How to Store and Dispose of This Medicine:

  • Store at room temperature, away from heat, light, and moisture.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children.
Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are taking digoxin, phenytoin (Dilantin®) or medicines that could make you drowsy such as sleeping pills, tranquilizers, other medicine for depression, cold or allergy medicine, or narcotic pain killers.
Warnings While Using This Medicine:

  • If you are pregnant or breastfeeding, talk to your doctor before taking this medicine.
  • Do not suddenly stop taking this medicine without first checking with your doctor.
  • You may need to take trazodone for 2 to 4 weeks before you start to feel better.
  • Get up slowly from a lying or sitting position to decrease dizziness caused by this medicine.
  • Trazodone can make you dizzy or drowsy. Be careful if driving a car or using machinery.
Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Skin rash, hives
  • Unexplained fever or sore throat
  • Unwanted and painful erection (erect penis) that does not go away

If you notice these less serious side effects, talk with your doctor:

  • Changes in vision such as trouble focusing
  • Constipation or diarrhea
  • Drowsiness or dizziness
  • Dry mouth
  • Headache
  • Nausea, vomiting, upset stomach
  • Nervousness, trouble sleeping
If you notice other side effects that you think are caused by this medicine, tell your doctor.

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