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You are here : 3-RX.com > Drugs & Medications > Detailed Drug Information (USP DI) > Angiotensin-converting Enzyme (ACE) Inhibitors and Hydrochlorothiazide

Angiotensin-converting Enzyme (ACE) Inhibitors and Hydrochlorothiazide (Systemic)

Description and Brand Names | Before Using | Proper Use | Precautions | Side Effects | Additional Information

  • Antihypertensive - Benazepril and Hydrochlorothiazide; Captopril and Hydrochlorothiazide; Enalapril and Hydrochlorothiazide; Lisinopril and Hydrochlorothiazide; Moexipril and Hydrochlorothiazide; Quinapril and Hydrochlorothiazide
  • Vasodilator, congestive heart failure - Captopril and Hydrochlorothiazide; Enalapril and Hydrochlorothiazide; Lisinopril and Hydrochlorothiazide

This combination belongs to the class of medicines called high blood pressure medicines (antihypertensives). It is used to treat high blood pressure (hypertension).

High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

The exact way in which benazepril, captopril, enalapril, lisinopril, moexipril, and quinapril work is not known. They block an enzyme in the body that is necessary to produce a substance that causes blood vessels to tighten. As a result, they relax blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart. Hydrochlorothiazide helps reduce the amount of salt and water in the body by acting on the kidneys to increase the flow of urine; this also helps to lower blood pressure.

This combination may also be used for other conditions as determined by your doctor.

This medicine is available only with doctor's prescription, in the following dosage forms:

  • Benazepril and Hydrochlorothiazide
    • Tablets (U.S.)
  • Captopril and Hydrochlorothiazide
    • Tablets (U.S.)
  • Enalapril and Hydrochlorothiazide
    • Tablets (U.S. and Canada)
  • Lisinopril and Hydrochlorothiazide
    • Tablets (U.S. and Canada)
  • Moexipril and Hydrochlorothiazide
    • Tablets (U.S.)
  • Quinapril and Hydrochlorothiazide
    • Tablets (U.S. and Canada)

Brand Names

Some commonly used brand names are:

In the U.S. -

  • Accuretic 6
  • Capozide 2
  • Lotensin HCT 1
  • Prinzide 4
  • Uniretic 5
  • Vaseretic 3
  • Zestoretic 4

In Canada -

  • Accuretic 6
  • Prinzide 4
  • Vaseretic 3
  • Zestoretic 4


For quick reference, the following medicines are numbered to match the corresponding brand names.

This information applies to the following medicines:
1. Benazepril and Hydrochlorothiazide (ben-AY-ze-pril and hye-droe-klor-oh-THYE-a-zide)†
2. Captopril and Hydrochlorothiazide (KAP-toe-pril)†‡
3. Enalapriland Hydrochlorothiazide (e-NAL-a-pril)
4. Lisinopril and Hydrochlorothiazide (lyse-IN-oh-pril)
5. Moexipriland Hydrochlorothiazide (moe-EX-i-pril)†
6. Quinapril and Hydrochlorothiazide (KWIN-a-pril)
† Not commercially available in Canada
‡ Generic name product may be available in the U.S.

† Not commercially available in Canada.


Next section


Angiotensin-converting Enzyme (ACE) Inhibitors and Hydrochlorothiazide: Before Using

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