Colony Stimulating Factors (Systemic)
Before Using This Medicine
In deciding to use a medicine,
the risks of taking the medicine must be weighed against the good it will
do. This is a decision you and your doctor will make. For colony stimulating
factors, the following should be considered:
Allergies - Tell your doctor if you have ever had any unusual or
allergic reaction to the colony stimulating factor. Also tell your health
care professional if you are allergic to any other substances, such as foods,
preservatives, or dyes.
Pregnancy - Colony stimulating factors have not been studied
in pregnant women.
In studies in rabbits,
filgrastim did not cause birth defects but did cause internal defects, a decrease
in average weight, and death of the fetus at high doses.
Studies on birth defects
have not been done in animals.
Breast-feeding - It is not known whether colony stimulating factors
pass into human breast milk. However, these medicines have not been reported
to cause problems in nursing babies.
Children - Although there is no specific information comparing
use of colony stimulating factors in children with use in other age groups,
this medicine is not expected to cause different side effects or problems
in children than it does in adults. In Canada, data from clinical trials in
children indicate that the safety of filgrastim is similar in both adults
and children receiving certain cancer medicines.
Older adults - Many medicines have not been studied specifically
in older people. Therefore, it may not be known whether they work exactly
the same way they do in younger adults. Although there is no specific information
comparing use of colony stimulating factors in the elderly with use in other
age groups, this medicine has been used in many elderly patients and is not
expected to cause different side effects or problems in older people than
it does in younger adults.
Other medicines - Although certain medicines should not be used
together at all, in other cases two different medicines may be used together
even if an interaction might occur. In these cases, your doctor may want to
change the dose, or other precautions may be necessary. Tell your health care
professional if you are taking any other prescription or nonprescription (over-the-counter
Other medical problems - The presence of other medical
problems may affect the use of colony stimulating factors. Make sure you tell
your doctor if you have any other medical problems, especially:
Conditions caused by inflammation or immune system problems - There
is a chance these may be worsened by colony stimulating factor
Heart disease - Risk of some unwanted effects (heart rhythm problems,
retaining water) may be increased
Kidney disease or
Liver disease - May sometimes be worsened by colony stimulating
Lung disease - Colony stimulating factor may cause shortness