3-rx.comCustomer Support
3-rx.com
   
HomeAbout UsFAQContactHelp
News Center
Health Centers
Medical Encyclopedia
Drugs & Medications
Diseases & Conditions
Medical Symptoms
Med. Tests & Exams
Surgery & Procedures
Injuries & Wounds
Diet & Nutrition
Special Topics



\"$alt_text\"');"); } else { echo"\"$alt_text\""; } ?>


Join our Mailing List





Syndicate

You are here : 3-RX.com > Home > Weight Loss -

Lifestyle change adds to weight-loss drug’s effect

Weight LossNov 17, 05

Obese patients who took the diet drug Meridia and received intensive weight-loss counseling lost twice as much weight as patients who only took the drug, according to a study released on Wednesday.

Nearly a third of Americans are considered overweight and the U.S. Food and Drug Administration regards a diet pill as effective if it helps a 200-pound (90-kg) person lose at least 10 pounds (4.5 kg) in a year. Although most obese people need to lose far more than 10 pounds (4.5 kg), doctors contend even a moderate loss has health benefits.

Meridia, generically known as sibutramine, and Roche’s Xenical are the only diet drugs licensed by the FDA.

In the study of Abbott Laboratories Inc.‘s Meridia, published in the New England Journal of Medicine, researchers found that when the drug was combined with 30 weight-loss counseling sessions lasting 90 minutes each, the treatment produced an average weight loss of 27 pounds (12.1 kg) for 60 volunteers.

The counseling ranged from advice on healthier eating habits to other behavioral changes that can reduce weight.

Another 55 patients took the drug but received no counseling and lost 11 pounds (5 kg). A third group of 55 volunteers, who only received counseling, lost an average of 15 pounds (1.7 kg).

Patients typically weighed about 240 pounds (108 kg) at the start of the study, which was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases.

The researchers, led by Thomas Wadden of the University of Pennsylvania School of Medicine, also found that obese patients who received both the drug and counseling lost the most when they recorded how much food they were eating.

Those who regularly logged their consumption shed 49 pounds (18.1 kg) versus 17 pounds (7.7 kg) among those who did not track what they ate.

A separate study, also published in the journal, examined the experimental diet medicine Acomplia, or rimonabant. The study was financed by Sanofi-Aventis SA, the drug’s manufacturer.

Participants in the study weighed 192 pounds (96 kg) on average and had high cholesterol.

Thirty-three percent of patients who ate a low-calorie diet and took 20 milligrams of Acomplia every day for a year lost an average of 15 pounds (6.9 kg) and three inches (7.1 cm) from their waistlines. Their “good” cholesterol levels also climbed, the study said.

Placebo recipients lost three pounds (1.5 kg) and an inch (2.4 cm) from their waists.

But more than a third of the study’s 1,036 volunteers dropped out of the study, complaining mostly of depression, anxiety and nausea.

In an editorial in the journal, Susan Yanovski of the National Institute of Diabetes and Digestive and Kidney Diseases, characterized the weight loss from Acomplia as “moderate” and comparable to other drugs.

She cautioned that while weight loss seems to improve risk factors such as blood pressure, “no study has yet demonstrated conclusively that any weight-loss treatment” actually reduces the risk of heart disease.

And she said it remains uncertain whether obese people who lose weight end up being as healthy as people who were never obese.



Print Version
Tell-a-Friend
comments powered by Disqus

RELATED ARTICLES:
  Don’t Blame Breast Density; $$$ Toxicity; ‘Nurse Ratched’ Returns
  Early Heart Data Look Good for Obesity Drug
  Sexual function dramatically improves in women following bariatric surgery, Penn study finds
  Glowing fish shed light on metabolism
  Gastric bypass for weight loss increases alcohol use, study says
  Obesity Costs Twice as Much
  Patients with diabetes may need fewer medications after bariatric surgery
  Sleep problems linked to weight gain in middle-age
  Community interventions and in-home visits may slow excess weight gain in American Indian children
  Eating Breakfast Boosts Weight Loss
  Obesity May be Evaded by Weight Loss Surgery
  Vitamin D, Weight Loss, and Obesity

 












Home | About Us | FAQ | Contact | Advertising Policy | Privacy Policy | Bookmark Site