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You are here : 3-RX.com > Medical Encyclopedia > Tests and Exams > CPK Isoenzymes

CPK Isoenzymes

Alternate Names : Creatine Kinase-Isoenzymes, Creatine Phosphokinase-Isoenzymes, CK-Isoenzymes

Overview & Description | Preparation & Expectations | Results and Values

This test measures the blood levels of three forms of the enzyme creatine phosphokinase, which is also called CPK. These forms are known as isoenzymes. They are called CPK-BB, CPK-MB, and CPK-MM.

This blood test determines the amounts of each of these isoenzymes in the blood. These levels can help a doctor to diagnose certain illnesses and conditions.

  • CPK-BB is found mainly in the brain and lungs.
  • CPK-MB is found mainly in the heart.
  • CPK-MM is found mainly in skeletal muscle.
  • Damage to the brain, lungs, heart, or muscle may cause the corresponding isoenzyme to leak into the bloodstream.

    How is the test performed?

    In order to measure the amount of CPK isoenzymes in the blood, a blood sample is taken from a vein on the forearm or hand. First, the skin over the vein is cleaned with an antiseptic. Next, a rubber tube called a tourniquet is tied around the upper arm. This enlarges the veins in the lower arm by restricting blood flow through them. A fine needle is gently inserted into a vein, and the tourniquet is removed. Blood flows from the vein through the needle and is collected in a syringe or vial for testing in the laboratory. After the needle is withdrawn, the puncture site is covered for a short time to prevent bleeding.


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    CPK Isoenzymes: Preparation & Expectations

    Author: David T. Moran, MD
    Reviewer: Adam Brochert, MD

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