Isoniazid and Thiacetazone (Systemic)
Brand Names : INAT, Thiazina, Thisozide, INH, thioacetazone, amithiozone
Before Using This MedicineIn deciding to use a medicine,
the risks of taking the medicine must be weighed against the good it will
do. This is a decision you and your doctor will make. For isoniazid and thiacetazone
combination, the following should be considered:
Allergies - Tell your doctor if you have ever had any unusual or
allergic reaction to isoniazid or thiacetazone. Also tell your health care
worker if you are allergic to any other substances, such as foods, preservatives,
or dyes.
Pregnancy - Isoniazid has not been shown to cause birth defects
or other problems in humans and has not been shown to cause birth defects
in animals. Studies in rats and rabbits have shown that isoniazid may increase
the risk of miscarriage. However, tuberculosis is a very serious disease and
many women have been treated with isoniazid during pregnancy with no problems
occurring in their babies. Studies on the effects of thiacetazone in pregnancy
have not been done in humans or animals.
Breast-feeding - Isoniazid passes into the breast milk. However,
isoniazid has not been reported to cause problems in nursing babies. Also,
there is not enough isoniazid in breast milk to protect or treat babies who
have been exposed to tuberculosis. It is not known whether thiacetazone passes
into breast milk.
Children - Isoniazid and thiacetazone combination can cause
serious side effects in any patient. Therefore, it is especially important
that you discuss with the child's doctor the good that this medicine may do
as well as the risks of using it.
Older adults - Hepatitis may be especially likely to occur in older
patients, who are usually more sensitive than younger adults to the effects
of isoniazid.
Other medicines - Although certain medicines should not be used
together at all, in other cases two different medicines may be used together
even if an interaction might occur. In these cases, your doctor may want to
change the dose, or other precautions may be necessary. When you are taking
isoniazid and thiacetazone combination, it is especially important that your
health care worker know if you are taking any of the following:
-
Acetaminophen (e.g., paracetamol, Tylenol) (with long-term, high-dose
use) or
-
Amiodarone (e.g., Cordarone) or
-
Anabolic steroids (nandrolone [e.g., Anabolin], oxandrolone [e.g.,
Anavar], oxymetholone [e.g., Anadrol], stanozolol [e.g., Winstrol]) or
-
Androgens (male hormones) or
-
Antithyroid agents (medicine for overactive thyroid) or
-
Carmustine (e.g., BiCNU) or
-
Chloroquine (e.g., Aralen) or
-
Dantrolene (e.g., Dantrium) or
-
Daunorubicin (e.g., Cerubidine) or
-
Divalproex (e.g., Depakote) or
-
Estrogens (female hormones) or
-
Etretinate (e.g., Tegison) or
-
Gold salts (medicine for arthritis) or
-
Hydroxychloroquine (e.g., Plaquenil) or
-
Mercaptopurine (e.g., Purinethol) or
-
Methotrexate (e.g., Mexate) or
-
Methyldopa (e.g., Aldomet) or
-
Naltrexone (e.g., Trexan) (with long-term, high-dose use) or
-
Oral contraceptives (birth control pills) containing estrogen or
-
Other anti-infectives by mouth or by injection (medicine for infection)
or
-
Phenothiazines (acetophenazine [e.g., Tindal], chlorpromazine [e.g.,
Thorazine], fluphenazine [e.g., Prolixin], mesoridazine [e.g., Serentil],
perphenazine [e.g., Trilafon], prochlorperazine [e.g., Compazine], promazine
[e.g., Sparine], promethazine [e.g., Phenergan], thioridazine [e.g., Mellaril],
trifluoperazine [e.g., Stelazine], triflupromazine [e.g., Vesprin], trimeprazine
[e.g., Temaril]) or
-
Plicamycin (e.g., Mithracin) or
-
Rifampin (e.g., Rifadin) or
-
Valproic acid (e.g., Depakene) - These medicines may increase
the chance of liver damage if taken with isoniazid and thiacetazone combination
-
Carbamazepine (e.g., Tegretol) or
-
Phenytoin (e.g., Dilantin) - These medicines may increase the
chance of liver damage if taken with isoniazid and thiacetazone combination.
There may also be an increased chance of side effects of carbamazepine and
phenytoin
-
Disulfiram (e.g., Antabuse) - Use of this medicine with isoniazid
and thiacetazone combination may increase the chance of liver damage and side
effects, such as dizziness, lack of coordination, irritability, and trouble
in sleeping
-
Ketoconazole (e.g., Nizoral) - Use of ketoconazole with isoniazid
and thiacetazone combination can lower the blood levels of ketoconazole decreasing
its effects
Other medical problems - The presence of other medical
problems may affect the use of isoniazid and thiacetazone combination. Make
sure you tell your doctor if you have any other medical problems, especially:
-
Alcohol abuse (or history of) or
-
Liver disease - There may be an increased chance of hepatitis
with daily drinking of alcohol or in patients with liver disease
-
Human immunodeficiency virus (HIV) infection - There may be an
increased chance of severe skin rash in patients with HIV infection
-
Kidney disease (severe) - There may be an increased chance of
side effects in patients with severe kidney disease
-
Seizure disorders such as epilepsy - There may be an increased
chance of seizures (convulsions) in some patients
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