Isoniazid and Thiacetazone (Systemic)

Brand Names : INAT, Thiazina, Thisozide, INH, thioacetazone, amithiozone

Proper Use of This Medicine

If you are taking isoniazid and thiacetazone combination and it upsets your stomach, take it with food. Antacids may also help. However, do not take aluminum-containing antacids within 1 hour of taking isoniazid and thiacetazone combination. They may keep this medicine from working properly.

To help clear up your tuberculosis (TB) completely, it is very important that you keep taking this medicine for the full time of treatment , even if you begin to feel better after a few weeks. You may have to take it every day for as long as 8 to 12 months. It is important that you do not miss any doses .

Your doctor may also want you to take pyridoxine (e.g., Hexa-Betalin, vitamin B ₆ ) every day during treatment with isoniazid and thiacetazone combination to help prevent or lessen some of the side effects of the combination. Pyridoxine is not usually needed in children who receive enough pyridoxine in their diet. If pyridoxine is needed, it is very important to take it every day along with this medicine. Do not miss any doses .

Dosing - The dose of isoniazid and thiacetazone combination will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of isoniazid and thiacetazone combination. If your dose is different, do not change it unless your doctor tells you to do so.

The number of tablets that you take depends on the strength of the medicine.

• For oral dosage form (tablets):
  • For treatment of tuberculosis:
    • Adults, teenagers, and children over 40 kilograms (kg) (88 pounds) of body weight - 300 milligrams (mg) of isoniazid and 150 mg of thiacetazone once a day.
    • Children up to 10 kg (22 pounds) of body weight - 50 mg of isoniazid and 25 mg of thiacetazone once a day.
    • Children 10 to 20 kg (22 to 44 pounds) of body weight - 100 mg of isoniazid and 50 mg of thiacetazone once a day.
    • Children 20 to 30 kg (44 to 66 pounds) of body weight - 200 mg of isoniazid and 100 mg of thiacetazone once a day.
    • Children 30 to 40 kg (66 to 88 pounds) of body weight - 250 mg of isoniazid and 125 mg of thiacetazone once a day.

Missed dose - If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage - To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store this medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.