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Type 2 Diabetes (T2D) and other chronic diseases are caused by a complex combination of many genetic and environmental factors. Few methods are available to comprehensively associate specific physical environmental factors with disease. We conducted a pilot Environmental-Wide Association Study (EWAS), in which epidemiological data are comprehensively and systematically interpreted in a manner analogous to a Genome Wide Association Study (GWAS).
Methods and Findings
We performed multiple cross-sectional analyses associating 266 unique environmental factors with clinical status for T2D defined by fasting blood sugar (FBG) concentration ≥126 mg/dL. We utilized available Centers for Disease Control (CDC) National Health and Nutrition Examination Survey (NHANES) cohorts from years 1999 to 2006. Within cohort sample numbers ranged from 503 to 3,318. Logistic regression models were adjusted for age, sex, body mass index (BMI), ethnicity, and an estimate of socioeconomic status (SES). As in GWAS, multiple comparisons were controlled and significant findings were validated with other cohorts. We discovered significant associations for the pesticide-derivative heptachlor epoxide (adjusted OR in three combined cohorts of 1.7 for a 1 SD change in exposure amount; p<0.001), and the vitamin γ-tocopherol (adjusted OR 1.5; p<0.001). Higher concentrations of polychlorinated biphenyls (PCBs) such as PCB170 (adjusted OR 2.2; p<0.001) were also found. Protective factors associated with T2D included β-carotenes (adjusted OR 0.6; p<0.001).
Dieting to shed weight is on its own not enough to stave off diabetes in people with sarcopenia — low skeletal muscle mass and strength, a study has claimed.
Sarcopenia is often found in obese people and older adults and it has been hypothesized that it puts individuals at risk for developing Type 2 diabetes.
To gauge the effect of sarcopenia on insulin resistance (the root cause of Type 2 diabetes) and blood glucose levels in both obese and non-obese people, UCLA researchers performed a cross-sectional analysis of data on 14,528 people from the National Health and Nutrition Examination Survey III.
National Agenda for Public Health Action: A National Public Health Initiative on Diabetes and Women’s Health
What do we want?
The National Agenda for Action is founded on a realistic vision and on specific and attainable goals. These are consistent with the framework of Healthy People 2010, which establishes national targets that address primary prevention of diabetes and prevention of complications related to the disease.
* Diabetes among women can and should be prevented or at least delayed whenever possible.
* The families and communities of women at risk for diabetes can and should be informed and provided the support they need to prevent or delay diabetes and its complications.
* Appropriate care and management of diabetes can and should be promoted among women across the life stages.
* The complications of diabetes among women can and should be prevented, delayed, or minimized.
Since Leonard F.C. Wendt, MD, opened the doors of the first diabetes camp in Michigan in 1925, the concept of specialized residential and day camps for children with diabetes has become widespread throughout the U.S. and many other parts of the world. It is estimated that worldwide camps serve 15,000–20,000 campers with diabetes each summer.
The mission of camps specialized for children and youth with diabetes is to facilitate a traditional camping experience in a medically safe environment. An equally important goal is to enable children with diabetes to meet and share their experiences with one another while they learn to be more responsible for their condition. For this to occur, a skilled medical and camping staff must be available to ensure optimal safety and an integrated camping/educational experience.
DIABETES MANAGEMENT AT CAMP
The recommendations for diabetes management of children at a diabetes camp are not significantly different from what has been outlined by the American Diabetes Association (ADA) as the standards of care for people with type 1 diabetes or for children with diabetes in the school or day care setting.
DEFINITION AND DESCRIPTION OF DIABETES MELLITUS
Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels.
Several pathogenic processes are involved in the development of diabetes. These range from autoimmune destruction of the ß-cells of the pancreas with consequent insulin deficiency to abnormalities that result in resistance to insulin action. The basis of the abnormalities in carbohydrate, fat, and protein metabolism in diabetes is deficient action of insulin on target tissues. Deficient insulin action results from inadequate insulin secretion and/or diminished tissue responses to insulin at one or more points in the complex pathways of hormone action. Impairment of insulin secretion and defects in insulin action frequently coexist in the same patient, and it is often unclear which abnormality, if either alone, is the primary cause of the hyperglycemia.
People with type 2 diabetes—formerly known as adult-onset diabetes—are more likely to get 24 kinds of cancer than the general population, according to a new study.
Researchers in Sweden and the U.S. reviewed records of more than 125,000 people in Sweden who had been hospitalized for complications of diabetes.
They found that the greatest increase in risk was for pancreatic and liver cancers. People with diabetes were six times more likely to get pancreatic cancer and 4.25 times more likely to get liver cancer.
You might want to think twice before grilling up those breakfast sausages as a new study has linked processed meat consumption to heart disease and diabetes.
Some of our favorite foods may not be doing us any good, as according to researchers, eating processed meat can up our risk of heart disease by 42 percent, and our risk of diabetes by 19 percent.
Processed meats include; bacon, hotdogs, lunch meat to name a few, all of which are considered popular food items when it comes to the diet of Americans.
All three of Val and Diane Henson’s daughters were diagnosed with type 1 diabetes as young children.
As devastating as that news was, it was one nightmarish incident about 14 years ago that spurred the Lake Forest family to become champions for a cure.
Clare, the youngest, was 4 years old when her blood sugar dropped so suddenly in her sleep that she nearly stopped breathing.
Researchers say more studies need to be conducted to determine whether taking Chinese herbal medicines can reduce the risk of developing diabetes.
Herbal teas, pills and powders are used in many Asian countries to treat pre-diabetes as well as diabetes. They are thought to work in a number of different ways to help normalize blood sugar levels, including improving pancreatic function and increasing the availability of insulin—a hormone that regulates blood sugar levels.
Cochrane researchers studied data on the effectiveness of 15 different herbal formulations gathered from 16 separate clinical trials. They said that combining herbal medicines with lifestyle changes is twice as effective as lifestyle changes alone at normalizing patients’ blood sugar levels.
A new study shows eating processed red meat—such as hot dogs, bacon, sausage, and cold cuts—is linked to increased risks of heart disease and diabetes.
But the study, published in Circulation, shows no such link for unprocessed red meat.
Eating one serving a day of processed meat—or the equivalent of a single hot dog or two slices of salami—was associated with a 42% increased risk for heart disease and a 19% increased risk for diabetes in the study, conducted by researchers from the Harvard School of Public Health.
A husband-and-wife research team at the UC Davis School of Medicine has been awarded a five-year, $3.3 million grant to lead a nationwide study on how to prevent brain swelling in children with diabetes.
A “diabetic crisis” occurs when the body releases acidic ketones into the blood, a byproduct of burning fat stores for energy. They can result in neurological injuries and sometimes death.
The award’s recipients are Nathan Kuppermann, professor of emergency medicine and pediatrics and chair of the Department of Emergency Medicine, and Nicole Glaser, associate professor of pediatric endocrinology. The Eunice Kennedy Shriver National Institute of Child Health and Human Development is funding the grant.
That is one way to keep Diabetes at bay. Zeenia F Baria speaks to the experts.
The number of diabetics is increasing at an alarming level all of the globe. And one of the topmost reasons for this increase in numbers is the lifestyle that people have adopted in recent years.
Obesity and Bariatric surgeon, Dr Mufazzal Lakdawala says that Diabetes can be described as a disease in which the body either does not produce enough insulin or does not utilise the produced insulin properly leading to a high blood glucose level. “There are two types of diabetes — Type 1 diabetes, in which there is no generation of insulin in the body and Type 2 diabetes, in which the cells in the body become resistant to insulin.
A recent study indicates that coronary disease casualties are starting to fall in Ontario, but having diabetes significantly increases the risk of cardiac arrest . The study has established that a 35 per cent decrease in deaths from coronary disease occurred between 1994 and 2005, largely due to healthier lifestyles .
A research team at Sunnybrook Health Sciences Centre in Toronto partnered with other institutes such as the University of Liverpool and the Canadian Heart Research Centre to reach their conclusions.
Have you just been diagnosed with type 2 diabetes? Are you looking for a type 2 diabetes cure? Find out the truth about type 2 diabetes cure.
The Type 2 Diabetes
Diabetes may be classified as either type 1 or type 2. A type 1 diabetes is a more severe condition because people suffering from this condition do not produce adequate insulin to regulate glucose levels. It is believed that genetic factors may play a big role in the development of type 1 diabetes. Type 2 on the other hand is characterized by insulin resistance. A type 2 diabetic’s pancreas may be fully functional but the body’s cells are resistant to the influence of insulin and do not take in as much glucose for cell energy production.
Most Americans with diabetes have type 2 diabetes. Although it is as devastating as type 1, it can be easier to manage especially when detected early because it does not involve a defective pancreas.