3-rx.comCustomer Support
HomeAbout UsFAQContactHelp
News Center
Health Centers
Medical Encyclopedia
Drugs & Medications
Diseases & Conditions
Medical Symptoms
Med. Tests & Exams
Surgery & Procedures
Injuries & Wounds
Diet & Nutrition
Special Topics

\"$alt_text\"');"); } else { echo"\"$alt_text\""; } ?>

Join our Mailing List


You are here : 3-RX.com > Home > Cancer - Breast Cancer - Endocrinology -

Hormone therapy raises breast cancer deaths -study

Cancer • • Breast Cancer • • EndocrinologyOct 20, 10

Women who took hormone replacement pills had more advanced breast cancers and were more likely to die from them than women who took a dummy pill, raising new concerns about the commonly prescribed drugs, U.S. researchers said on Tuesday.

The study, published in the Journal of the American Medical Association, is the first to report more breast cancer deaths among women taking hormone replacement therapy.

And it contradicts prior studies that suggest women taking the drugs had less aggressive, easier-to-treat breast cancers.

“As opposed to the prevailing thought of two years ago, that cancers associated with estrogen plus progesterone would be favorable and not much of a problem, we are actually showing they are associated with an increased risk of death from breast cancer,” Dr. Rowan Chlebowski of the Los Angeles Biomedical Research Institute, who led the study, said in a telephone interview.

The findings include 11 years of follow-up from the Women’s Health Initiative study, which in 2002 found women who took estrogen plus progesterone for five years had higher rates of ovarian cancer, breast cancer, strokes and other health problems.

Sales of U.S. market leader Wyeth’s combined estrogen plus progesterone pill Prempro have fallen by about 50 percent since 2001 to around $1 billion a year. Wyeth is now owned by Pfizer.


Chlebowski’s team analyzed data on the more than 12,000 women in the study. They found twice as many taking HRT died from breast cancer - 2.6 per 10,000 per year versus 1.3 per 10,000 women per year - compared to women who took a placebo.

Nearly 24 percent of the breast cancer patients who took HRT had tumors that had spread to the lymph notes, compared with 16 percent of women taking placebos.

“All the scary cancers with unfavorable prognoses were also increased,” Chlebowski said, citing increases in aggressive forms of breast cancer, and not just estrogen-fed cancers that are easier to treat.

“And then for the first time we show deaths from breast cancer are significantly increased as well,” he said.

Pfizer said in a statement the company stands behind Prempro’s current labeling, which advises doctors to prescribe the drug at the lowest effective dose for the shortest possible period of time.

But even that may be risky, suggests Dr. Peter Bach of Memorial Sloan-Kettering Cancer Center in New York, who wrote a commentary in the same journal.

Doctors can only be guessing that taking the pills at a lower dose and for a shorter time would be less harmful, Bach said in a telephone interview.

Doctors “should be aware that this approach has not been proven in rigorous clinical trials,” Bach wrote.

“As a science-based company, we take this analysis seriously,” Pfizer said in a statement.

“It is important to view the data in the full context of both the symptoms of menopause as well as the extensive body of information - developed over more than 60 years - on the known benefits and risks of hormone therapy.”

Doctors note that the average age of the women in the Women’s Health Initiative study was 63, several years past menopause, and say the findings may not apply to women taking other forms of HRT, or to those starting HRT immediately at the time of menopause.

SOURCE:  Journal of the American Medical Association, October 20, 2010.

Print Version
comments powered by Disqus

  New biomarkers may influence drug design and alternative treatments of cancer, study shows
  Metabolic profiles distinguish early stage ovarian cancer with unprecedented accuracy
  Moffitt researchers develop first genetic test to predict tumor sensitivity to radiation therapy
  New drug for neuroblastoma shows promise in phase I study
  Experimental treatment sends deadly leukemia into remission
  Study could reduce unnecessary cancer screening
  UA researchers discover component of cinnamon prevents colorectal cancer in mice
  Profiling approach to enable right lung cancer treatment match
  What’s the life expectancy of patients when they begin treatment for osteoporosis?
  Widespread agricultural contaminant impacts fish reproductive behavior
  Fat grafting technique improves results of breast augmentation
  Germline TP53 mutations in patients with early-onset colorectal cancer


Home | About Us | FAQ | Contact | Advertising Policy | Privacy Policy | Bookmark Site