3-rx.comCustomer Support
HomeAbout UsFAQContactHelp
News Center
Health Centers
Medical Encyclopedia
Drugs & Medications
Diseases & Conditions
Medical Symptoms
Med. Tests & Exams
Surgery & Procedures
Injuries & Wounds
Diet & Nutrition
Special Topics

\"$alt_text\"');"); } else { echo"\"$alt_text\""; } ?>

Join our Mailing List


You are here : 3-RX.com > Home > AIDS/HIV -

U.S. drops trial of one AIDS vaccine

AIDS/HIVJul 18, 08

U.S. AIDS researchers are dropping plans to test one experimental vaccine in people, saying the high-profile failure of a Merck and Co. vaccine last year shows the need to do quicker, more focused studies.

The National Institute of Allergy and Infectious Diseases, part of the government’s National Institutes of Health, said on Thursday it was canceling the HIV vaccine study known as PAVE 100.

“However, NIAID believes the vaccine developed by its Vaccine Research Center (VRC) is scientifically intriguing and sufficiently different from previously tested HIV vaccines to consider testing it in a smaller, more focused clinical study,” the institute said in a statement.

It is the first demonstration of a new approach being taken by federal vaccine developers after a trial called STEP showed last year that Merck’s vaccine may have raised the risk of infection among certain men—those who had pre-existing immune responses to the virus used in the vaccine and who were not circumcised.

The vaccine used a common virus known as an adenovirus to carry bits of the AIDS virus. “It didn’t work, it wasn’t beneficial and there were the issues of risk for people who were uncircumcised,” NIAID director Dr. Anthony Fauci said in a telephone interview.

“I am entertaining a smaller, leaner, less-expensive trial,” Fauci added.

The new vaccine being tested by the Partnership for AIDS Vaccine Evaluation, or PAVE, was designed to be given as three injections of HIV genetic material, followed with a final boost of adenovirus.

“I do believe that it is worthwhile pursuing this concept of a DNA vaccine, but I don’t believe that we have enough information to warrant making that a large trial,” Fauci said.

Scientists had argued whether it was justified to go ahead with a large trial of a vaccine that could not be expected to protect people against infection in the hope of finding something in their biological responses that could help design a better vaccine down the road.

AIDS has killed 25 million people since it was first identified in the 1980s and it infects 33 million people globally. There is no cure although a cocktail of drugs can keep the infection suppressed.

“An HIV vaccine continues to be our best hope for ending the HIV pandemic,” the NIAID said.


Fauci said he decided it would be better to do smaller, more focused tests and if and when one of those gets a result, to follow that lead.

“We are in an interesting and, some would say, difficult period,” Fauci said. “The obvious empirical approaches have not worked.”

But while about 30 vaccines are being tested, none has come even close to preventing infection in people.

“Because the PAVE vaccine candidate is different from the STEP candidate, we can still learn something from testing the PAVE candidate in humans. It’s just not necessary to do so in a trial involving thousands, as called for in the PAVE 100 design,” International AIDS Vaccine Initiative president Seth Berkley said in a statement.

By Maggie Fox

“The decision by NIAID does not reflect paralysis in the AIDS vaccine field, or a lack of direction forward. In fact, it reflects the opposite. It reflects the dynamic learning that is the scientific process, that is pharmaceutical product development,” Berkley added.

Print Version
comments powered by Disqus

  Hepatitis C more prevalent than HIV/AIDS or Ebola yet lacks equal attention
  Cell-associated HIV mucosal transmission: The neglected pathway
  Offering option of initial HIV care at home increases use of ART
  HIV-1 movement across genital tract cells surprisingly enhanced by usurping antibody response
  Indonesia probes Bali tattoo HIV infection report
  Obama raises U.S. goal on fighting AIDS
  New device to test blood can spot cancer cells, HIV on the fly
  Rare HIV-positive individuals shed light on how body could effectively handle infection
  New research examines how HIV infections occur on the molecular level
  An answer to a longstanding question: How HIV infection kills T cells
  Researchers say uncover HIV, insulin resistance link
  Beatrice Hahn and George Shaw, Pioneers in HIV Research, to Join Penn Medicine


Home | About Us | FAQ | Contact | Advertising Policy | Privacy Policy | Bookmark Site