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You are here : 3-RX.com > Drugs & Medications > Detailed Drug Information (USP DI) > Beta-adrenergic Blocking Agents and Thiazide Diuretics

Beta-adrenergic Blocking Agents and Thiazide Diuretics (Systemic)

Description and Brand Names | Before Using | Proper Use | Precautions | Side Effects

  • Antihypertensive - Atenolol and Chlorthalidone; Bisprolol and Hydrochlorothiazide; Metoprolol and Hydrochlorothiazide; Nadolol and Bendroflumethiazide; Pindolol and Hydrochlorothiazide; Propranolol and Hydrochlorothiazide; Timolol and Hydrochlorothiazide

Beta-adrenergic blocking agent (more commonly, beta-blockers) and thiazide diuretic combinations belong to the group of medicines known as antihypertensives (high blood pressure medicine). Both ingredients of the combination control high blood pressure, but they work in different ways. Beta-blockers (atenolol, bisoprolol, metoprolol, nadolol, pindolol, propranolol, and timolol) reduce the work load on the heart as well as having other effects. Thiazide diuretics (bendroflumethiazide, chlorthalidone, and hydrochlorothiazide) reduce the amount of fluid pressure in the body by increasing the flow of urine.

High blood pressure adds to the work load of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Beta-blocker and thiazide diuretic combinations are available only with your doctor's prescription, in the following dosage forms:

  • Atenolol and chlorthalidone
    • Tablets (U.S. and Canada)
  • Bisoprolol and hydrochlorothiazide
    • Tablets (U.S.)
  • Metoprolol and hydrochlorothiazide
    • Tablets (U.S.)
  • Nadolol and bendroflumethiazide
    • Tablets (U.S. and Canada)
  • Pindolol and hydrochlorothiazide
    • Tablets (Canada)
  • Propranolol and hydrochlorothiazide
    • Extended-release capsules (U.S.)
    • Tablets (U.S. and Canada)
  • Timolol and hydrochlorothiazide
    • Tablets (U.S. and Canada)

Brand Names

Some commonly used brand names are:

In the U.S. -

  • Corzide 40/5 4
  • Corzide 80/5 4
  • Inderide 6
  • Inderide LA 6
  • Lopressor HCT 3
  • Tenoretic 50 1
  • Tenoretic 100 1
  • Timolide 10-25 7
  • Ziac 2

In Canada -

  • Corzide 4
  • Inderide 6
  • Tenoretic 1
  • Timolide 7
  • Viskazide 5


For quick reference, the following beta-adrenergic blocking agents and thiazide diuretics are numbered to match the corresponding brand names.

This information applies to the following medicines:
1. Atenolol and Chlorthalidone (a-TEN-oh-lole and klor-THAL-i-doan)‡
2. Bisoprolol and Hydrochlorothiazide (bis-OH-proe-lol and hye-droe-klor-oh-THYE-a-zide)†
3. Metoprolol and Hydrochlorothiazide (me-TOE-proe-lole and hye-droe-klor-oh-THYE-a-zide)†
4. Nadolol and Bendroflumethiazide (NAY-doe-lole and ben-droe-floo-meth-EYE-a-zide)
5. Pindolol and Hydrochlorothiazide (PIN-doe-lole and hye-droe-klor-oh-THYE-a-zide)*
6. Propranolol and Hydrochlorothiazide (proe-PRAN-oh-lole and hye-droe-klor-oh-THYE-a-zide)‡
7. Timolol and Hydrochlorothiazide (TIM-oh-lole and hye-droe-klor-oh-THYE-a-zide)
* Not commercially available in the U.S.
† Not commercially available in Canada
‡ Generic name product may be available in the U.S.


Next section


Beta-adrenergic Blocking Agents and Thiazide Diuretics: Before Using

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